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The provided 9W power adapter is said to fully charge the battery in three hours – as opposed to the standard model’s five hours – which is still quite sluggish by modern standards. The only area in which the Fire HD 8 Plus (2022) shows any improvement over its little sibling is with charging, and even that isn’t anything to shout about. Still, a little over 19 hours is nothing to sniff at, so this is a positive result overall. In keeping with the standard set by the above CPU results, the Fire HD 8 Plus (2022) produced decent gains over its 2020 predecessor in our battery rundown test, but failed to pip the standard Fire HD 8 (2022) in any meaningful way. In short, you’re not going to be playing high-resolution 3D games at fluid frame rates here, but games in the vein of Candy Crush and Angry Birds will run without issue. There are considerable gains over the 2020 HD 8 Plus, at least, with the 2022 model pulling roughly 27% ahead in the single-core benchmarks and more than 50% ahead in multicore.Īs with the standard Fire HD 8 (2022), the GFXBench app that we use to test GPU performance failed to work here, due to the Amazon Store only offering an outdated version – more on that in a bit. While more RAM is never a bad thing, its presence doesn’t translate into improved performance, with both the standard HD 8 and the Plus scoring near-identical results in our tests. The Fire HD 8 Plus (2022) runs on the same Hexa-core 2.0GHz MediaTek MT8169A processor as the standard model, but it’s paired here with 3GB of RAM as opposed to 2GB. While this is perfectly adequate for casual viewing of Netflix or YouTube, it’s going to feel something of a fuzzy step down compared to most modern smartphones.Īmazon Fire HD 8 Plus (2022) review: Performance and battery life Here, we’ve got the same 8in panel with a 1,280 x 800 resolution, and a pixel density of just 189ppi. Amazon Fire HD 8 Plus (2022) review: DisplayĪnother area in which the Plus does very little to distinguish itself from the standard Fire HD 8 (2022) is the display. The microSD card tray is on the bottom, and the two upward-firing speakers sit on the top. With the camera at the top, you’ll find the volume and power buttons on the right, with the USB-C and 3.5mm ports just below them. Still, another colour choice would have been nice.Īs with all of Amazon’s recent tablet output, the Fire HD 8 Plus (2022) is designed to be used in landscape orientation, with the selfie camera embedded in one of the long edges. The light grey chassis feels a little drab compared to the Denim and Rose colours offered by the standard version, but the textured back does feel slightly more premium under your fingers than the matte plastic. Amazon Fire HD 8 Plus (2022) review: Design and key featuresĪside from the different colour on the back panel, the Fire HD 8 Plus (2022) is identical to the standard version, with the same dimensions and thick black bezels surrounding the screen. On the pricier side is the Fire HD 10 (2021), which has a larger 10in display and better performance, with prices starting at £150 for 32GB storage and lockscreen ads. If you want to spend a little less, the standard Fire HD 8 (2022) with 32GB of storage and lockscreen ads costs an even £100, with the 64GB model priced at £130 and again, the option to remove the ads for £10 extra. Due to Amazon’s iron grip on the budget tablet market, the only real competition comes from inside the house. At the top, turn on or off Ask before accessing (recommended).Ĭlick a icon to remove the individual site exception.Under Privacy and security, click Site settings.Click Advanced in the left sidebar, and click Privacy & security.To manage your location sharing preferences: You can choose to allow or deny access to your location, and Opera will remember your choice for future visits to that site. By default, Opera asks you if you’d like to share your location the first time you visit a site that requests it. Setting location sharing preferences gives you control over how sites access your location. Opera will not share this information without your permission. You can choose whether or not to share your location when browsing. To do this, these sites may ask you to allow geolocation on the page. Some sites may ask to use your location to provide localized features, such as reviews for nearby shops or coupons from businesses located in your area. Member:ĭramatists Guild (council member), Directors Guild, Society of Stage Directors and Choreographers, National Academy of Recording Arts and Sciences (national trustee), American Society of Composers, Authors and Publishers (board member). Kennedy Center for the Performing Arts, Washington, DC, artistic director American Society of Composers, Authors, and Publishers, director of musical theatre workshops. Playhouse Theatre, New London, NH, director, 1966 RCA Records, New York City, artist and repertoire agent, 1969-71 John F. Education: Attended Juilliard School, 1960-64 Carnegie Mellon University, B.F.A., 1968. Full name, Stephen Lawrence Schwartz born March 6, 1948, in New York, NY son of Stanley Leonard (in business) and Sheila Lorna (a teacher maiden name, Siegal) Schwartz married Carole Ann Piasecki (an actress), Jchildren: Jessica Lauren, Scott Lawrence (a theatre director). 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That said, the game does have its own depth so it is by no means a simplistic button spammer. download full Version Pcīloody Roar 4 is a fighter that aims to stand out from the competition of its era by being focused more on accessibility so that anyone can pick it up and play without having to learn massive combos and frame timings. It’s tolerable and you shouldn’t push it. There’s not much to talk about aside from a couple of new inclusions added in exchange for some older ones that have been axed from this sequel. If you came here for the story you’ll be largely disappointed. Bloody Roar 4 is a fighting game from its early 2000s era. In simpler terms, it means that different parts of a program should focus on doing one thing well, without getting tangled up with unrelated tasks. The principle of Separation of Concerns (SoC) is a fundamental concept in software development that promotes breaking down a program into distinct and independent parts, with each part addressing a specific concern or responsibility. This principle is helpful in maintaining a clean and manageable codebase, which decreases the risk of detecting bugs. It cautions against introducing sophisticated functionalities like reminders, notifications, or color-coding unless they are absolutely necessary for the program's fundamental functionality.įollowing the YAGNI idea allows us to save time and effort by avoiding the construction of unnecessary features that may never be utilized or can be added later if necessary. Using YAGNI implies concentrating entirely on implementing the functionalities required to handle tasks, such as adding, deleting, and marking them as complete. To illustrate the YAGNI principle, let's consider a scenario where we're developing a program for managing a to-do list. This principle encourages simplicity and efficiency in software development. In other words, don't write code for things you don't currently need or anticipate needing in the future. It reminds us to avoid adding unnecessary features or functionality to our code. YAGNI is a helpful guideline for software developers. Additionally, it reduces the likelihood of introducing errors. Simplifying the code helps enhance its comprehensibility and adaptability for both yourself and other developers in the future. This added complexity can make the code harder to comprehend and maintain in the future. On the other hand, a more complex approach might involve using advanced mathematical formulas or incorporating unnecessary features that complicate the logic. This approach is easy to understand and requires only a few lines of code. A simple and straightforward approach would be to iterate over the list, sum up the numbers, and then divide the sum by the total count. Simplifying the code makes it easier to comprehend, maintain, and debug, reducing the possibility of errors or problems.įor example, let's say we need to write a program to calculate the average of a list of numbers. It suggests that we should strive to keep code and solutions as simple as possible. KISS emphasizes the importance of simplicity in software development. Remember, following the DRY principle not only helps you write cleaner and more organized code but also saves time and effort in the long run. You avoid having to repeat the same logic for area calculations, making your code more efficient and maintainable. This way, you can reuse the same function for all shapes by passing in the appropriate parameters. Instead of writing separate functions to calculate the area of each shape (e.g., a separate function for calculating the area of a square, another for a triangle, and so on), you can follow the DRY principle by creating a single function called calculateArea that takes the necessary parameters and returns the area. Imagine you're building a program that calculates the area of different shapes. The first programming principle in this list is DRY, which stands for "Don't Repeat Yourself." It means you should avoid duplicating code in your programs and instead strive to write reusable and modular code.ĭuplicating code can lead to several problems, such as increased maintenance efforts, higher chances of introducing bugs, and difficulty in making changes across multiple places. Understanding and applying these concepts to your coding approaches will enable you to create code that is not only functional but also clean and manageable. This article will explore 10 essential programming principles that every software developer should know. These principles act as guiding lights, helping developers write code that is robust, scalable, and easy to understand. To achieve this, software developers should familiarize themselves with a set of fundamental programming principles. However, writing code is not just about making things work it's also about creating code that is clean, efficient, and maintainable. Programming is a fascinating field that empowers individuals to create innovative and functional software solutions. 9 min read Photo by Arnold Francisca / Unsplash. These findings identify an important role of CMA-induced degradation of misfolded N-CoR in the neutralization of ER stress and suggest a possible role of misfolded N-CoR protein in the activation of oncogenic survival pathway in NSCLC cells. Genetic and chemical inhibition of Lamp2A, a rate limiting factor of CMA, significantly blocked the loss of N-CoR in NSCLC cells, suggesting a crucial role of CMA in N-CoR degradation. In NSCLC cells, misfolded N-CoR was found to be associated with Hsc70, a molecular chaperone involved in chaperone mediated autophagy (CMA). The misfolded N-CoR presented in NSCLC cells was linked to the amplification of ER stress and was subjected to degradation by NSCLC cell specific aberrant protease activity. The NSCLC cell specific N-CoR loss could be blocked by Kaletra, a clinical grade protease inhibitor and by genistein, an inhibitor of N-CoR misfolding previously characterized by us. Emerging evidence indicates that TPD52 isoform 1, a prostate-specific and androgen-responsive gene, contributes to the malignant progression of PCa. Indeed, our initial screening of N-CoR status in various leukemia and solid tumor cells revealed an APL like MCDL of N-CoR in primary and secondary tumor cells derived from non-small cell lung cancer (NSCLC). Aberrant chaperone-mediated autophagy (CMA) activation has been suggested as a tumorigenesis-promoting event in various cancers, although its roles in prostate cancer (PCa) remain elusive. In cancer, alterations of the CMA principal components, Hsc70 and Lamp2A protein and mRNA levels, have been described in. The role of CMA in different physiopathological processes has been studied for several years. Since N-CoR plays important role in cellular homeostasis in various tissues, therefore, we hypothesized that an APL like MCDL of N-CoR might also be involved in other malignancy. Chaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of vesicles formation. Recently, we reported a role of misfolded-conformation dependent loss (MCDL) of N-CoR in the activation of oncogenic survival pathway in acute promyelocytic leukemia (APL). Nuclear receptor co-repressor (N-CoR) plays important role in transcriptional control mediated by several tumor suppressor proteins. Autophagy is a highly conserved process that is responsible for the degradation of cytoplasmic material and is involved in both innate and adaptive immunity. Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cells. The cyclic GMP-AMP synthase-stimulator of interferon genes (cGAS-STING) pathway is critical in cancer immunity. Role of chaperone mediated autophagy (CMA) in the degradation of misfolded N-CoR protein in non-small cell lung cancer (NSCLC) cellsĪli, A.B., Nin, D.S., Tam, J., Khan, M. Her mother often took what were then known as "transportation jobs", serving on passenger railroads. Holiday, aged two, in 1917Įleanora grew up in Baltimore and had a very difficult childhood. Sadie Harris, then known as Sadie Fagan, married Philip Gough in 1920, but the marriage ended within two years. DeViese lived in Philadelphia, and Sadie Harris may have known him through her work. Other historians consider this an anomaly, probably inserted by a hospital or government worker. Some historians have disputed Holiday's paternity, as a copy of her birth certificate in the Baltimore archives lists her father as "Frank DeViese". Not long after Eleanora was born, Clarence abandoned his family to pursue a career as a jazz banjo player and guitarist. With no support from her parents, she made arrangements with her older, married half-sister, Eva Miller, for Eleanora to stay with her in Baltimore. Sarah moved to Philadelphia at age 19, after she was evicted from her parents' home in the Sandtown-Winchester neighborhood of Baltimore, Maryland, for becoming pregnant. Life and career 1915–1929: Childhood Įleanora Fagan was born on April 7, 1915, in Philadelphia to African American unwed teenage couple Clarence Halliday and Sarah Julia "Sadie" Fagan. Several films about her life have been released, most recently The United States vs. She was named one of the 50 Great Voices by NPR and was ranked fourth on the Rolling Stone list of "200 Greatest Singers of All Time" (2023). In 2000, she was also inducted into the Rock & Roll Hall of Fame as an early influence their website states that "Billie Holiday changed jazz forever". She was inducted into the Grammy Hall of Fame and the National Rhythm & Blues Hall of Fame. Holiday won four Grammy Awards, all of them posthumously, for Best Historical Album. Holiday died of cirrhosis on July 17, 1959, at age 44. Her final album, Lady in Satin, was released in 1958. Because of personal struggles and an altered voice, her final recordings were met with mixed reaction but were mild commercial successes. She was a successful concert performer throughout the 1950s with two further sold-out shows at Carnegie Hall. After a short prison sentence, she performed at a sold-out concert at Carnegie Hall. By the late 1940s, however, she was beset with legal troubles and drug abuse. Throughout the 1930s and 1940s, Holiday had mainstream success on labels such as Columbia and Decca. Collaborations with Teddy Wilson produced the hit " What a Little Moonlight Can Do", which became a jazz standard. She signed a recording contract with Brunswick in 1935. Īfter a turbulent childhood, Holiday began singing in nightclubs in Harlem, where she was heard by producer John Hammond, who liked her voice. She was known for her vocal delivery and improvisational skills. Her vocal style, strongly influenced by jazz instrumentalists, inspired a new way of manipulating phrasing and tempo. Nicknamed " Lady Day" by her friend and music partner, Lester Young, Holiday made a significant contribution to jazz music and pop singing. Billie Holiday (born Eleanora Fagan Ap– July 17, 1959) was an American jazz and swing music singer. At the start of the night, Jordin meets and bonds with Liam (Hollingsworth), but doesn’t get his name before getting separated and lost in a sea of Santas. Three best friends decide to go together: Jordin (King), a recently dumped art teacher looking to cut loose Ava, a shy woman hoping to run into her crush and Stella, a Christmas cynic with no interest in the Santa Summit whatsoever. Those films are streaming on Starz, except for Spider-Verse, which you can rent or buy on Amazon.It’s time for the annual Santa Summit, in which revelers put on Santa suits and hop around designated locations in town to eat, drink, and be merry. NOT CURRENTLY ON DISNEY+: Spider-Man: Into the Spider-Verse (2018), Venom: Let There Be Carnage (2021), Spider-Man: No Way Home (2021). Spider-Man: Across the Spider-Verse (2023) - Netflix.Spider-Man: No Way Home (2021) - Hulu, Starz, DirecTV.Venom: Let There Be Carnage (2021) - Starz, DirecTV, FuboTV.
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